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Target intelligence / Profile preview
Melanoma-associated Antigen Peptide (MAA Peptide)
- Target
- MAA Peptide
- Molecular classification
- Peptide, Antigen, Cancer/Testis Antigen, Proteoglycan
01
Overview
Melanoma-associated antigen peptides are short amino acid sequences derived from proteins that are highly expressed in melanoma cells. These peptides can be presented on the cell surface by MHC molecules, making them recognizable targets for T cells. Key families include MAGE and HMW-MAA. They are used in cancer immunotherapy to stimulate anti-tumor immunity and can serve as diagnostic markers.
- Other names
- MAGE Family PeptidesHigh Molecular Weight-Melanoma Associated AntigenHMW-MAACancer/Testis Antigens
02
Mechanism of action
Stimulation of anti-tumor T-cell responses, antibody-mediated targeting of tumor cells.
03
Biological functions
Immune recognitionT-cell activationCell adhesionCell migrationMetastasisEpitope presentation
04
Disease associations
MelanomaCancer
05
Safety considerations
Potential for off-target effectsAutoimmunityImmune-related adverse events
06
Biomarkers
MAGE-A1 expressionHMW-MAA expression
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