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Target intelligence / Profile preview
Melanoma-Associated Antigen Peptides
- Molecular classification
- Peptide, Antigen, Cancer/Testis Antigen
01
Overview
Melanoma-associated antigen peptides are short protein fragments derived from proteins that are uniquely or preferentially expressed in melanoma cells. These peptides are presented on the surface of tumor cells via MHC molecules and recognized by T cells, making them targets for cancer immunotherapy.
- Other names
- MAA PeptidesMelanoma AntigensTumor-Associated Antigen Peptides (Melanoma)
02
Mechanism of action
Stimulation of cytotoxic T lymphocytes (CTLs) and helper T cells via MHC presentation, leading to tumor cell lysis and immune-mediated tumor regression
03
Biological functions
Antigen PresentationT-cell ActivationImmune ResponseCell AdhesionMetastasis
04
Disease associations
MelanomaCancerImmune Evasion
05
Safety considerations
Off-target toxicity due to expression in immune-privileged sitesImmune-related adverse eventsTumor escape mechanisms
06
Interacting drugs
Peptide Vaccines
2 more in the full profile.
07
Biomarkers
Anti-peptide precursor frequency in PBMCsTumor regressionProlonged survivalHLA type
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