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Target intelligence / Profile preview
Melanoma differentiation-associated gene 5
- Molecular classification
- RIG-I-like receptors, dsRNA helicase enzyme
01
Overview
Melanoma differentiation-associated gene 5 (MDA5) is a cytosolic pattern recognition receptor that plays a crucial role in the innate immune response to viral infection. It detects long double-stranded RNA (dsRNA) and initiates antiviral responses by inducing type I interferons. Aberrant activity is linked to autoimmune diseases like dermatomyositis.
- Other names
- Melanoma differentiation-associated protein 5IFIH1
02
Mechanism of action
Not applicable, MDA5 is a target and not a drug
03
Biological functions
Innate immune responseViral dsRNA sensorType I interferon induction
04
Disease associations
AutoimmunityClinically amyopathic dermatomyositis (CADM)Rapidly progressive interstitial lung disease (RP-ILD)Type I interferonopathies
05
Safety considerations
Excessive type I interferon productionPotential for autoinflammatory responses due to aberrant activation
06
Biomarkers
Anti-MDA5 autoantibody
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