Melanoma highly expressed noncoding RNA (MHENCR)

Melanoma highly expressed noncoding RNA (MHENCR) is a long noncoding RNA (lncRNA) upregulated in melanoma, further increased in metastatic disease, and correlated with poor prognosis. MHENCR acts as a competing endogenous RNA by directly binding miR-425 and miR-489, thereby preventing them from repressing their targets, IGF1 and SPIN1, respectively. This leads to the activation of the PI3K-Akt signaling pathway, promoting melanoma cell proliferation, cell cycle progression, migration, and metastasis. Knockdown of MHENCR results in inhibition of cell proliferation, induction of apoptosis, and reduced melanoma growth and metastasis in vitro and in vivo. MHENCR is considered a potential prognostic biomarker and therapeutic target in melanoma[1][2][3][4].

Other names

CTD-3184A7.4Melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489Melanoma highly expressed noncoding RNAMHENCR

Acts as a competing endogenous RNA (ceRNA) that binds and sequesters miR-425 and miR-489. Upregulates target genes of miR-425 (IGF1) and miR-489 (SPIN1). Activates PI3K-Akt pathway via derepression of IGF1 and SPIN1.