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Target intelligence / Profile preview
Melanotransferrin (CD228)
- Target
- CD228
- Molecular classification
- Transferrin superfamily, Glycoprotein
01
Overview
Melanotransferrin (CD228) is a member of the transferrin superfamily, characterized as a heavily glycosylated, GPI-anchored membrane protein. It binds a single ferric iron atom and is highly expressed in melanoma and other cancers, as well as fetal tissues. It is involved in iron homeostasis, tumor progression, and regulation of cell differentiation, making it a therapeutic target for antibody-drug conjugates.
- Other names
- p97MELTFMAP97
02
Mechanism of action
Cytotoxic activity dependent on CD228 expression/internalization
03
Biological functions
Iron uptake/homeostasisRegulation of cellular proliferationRegulation of tumorigenesisRegulation of metastasisRegulation of migrationRegulation of osteogenic/adipogenic differentiationRegulation of chondrogenic differentiation
04
Disease associations
CancerMelanomaNon-small cell lung cancer (NSCLC)Triple-negative breast cancer (TNBC)Colorectal cancerPancreatic cancer
05
Safety considerations
Potential toxicity related to antibody-drug conjugate mechanismOff-target effects due to expression in fetal tissue
06
Interacting drugs
SGN-CD228A
07
Biomarkers
CD228 expression in tumor tissueDifferential expression levels in hBM-MSCs or fibroblasts
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