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Target intelligence / Profile preview
Melatonin Receptor MT1 (MT1)
- Target
- MT1
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor
01
Overview
The human Melatonin Receptor MT1 is a GPCR crucially involved in regulating circadian rhythms—especially REM sleep—and modulating mood through inhibitory signaling pathways primarily mediated by Gi proteins. Its distinct anatomical distribution underlies its specialized physiological roles. Ongoing research aims at developing selective drugs targeting this receptor subtype for improved treatment outcomes across multiple neuropsychiatric conditions.
- Other names
- Melatonin receptor type 1MTNR1AMelatonin receptor 1A
02
Mechanism of action
Agonist binding inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels and subsequent downstream effects.
03
Biological functions
Signal transductionCircadian rhythm regulationSleep regulationInhibition of adenylate cyclaseRegulation of potassium conductance
04
Disease associations
InsomniaDepressionAnxiety DisordersAlzheimer's disease (possible)Huntington's disease (possible)Addiction (possible)
05
Safety considerations
Potential for limited efficacy of mixed MT1/MT2 ligands due to opposing roles between subtypes.Age-related decrease in expression may impact therapeutic efficacy.
06
Interacting drugs
Melatonin
1 more in the full profile.
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