Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI-2)

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (MAGI-2) is a scaffold protein encoded by the MAGI2 gene, characterized by two WW domains, multiple PDZ domains, and a guanylate kinase–like domain[1][2][4][5]. It is a member of the membrane-associated guanylate kinase (MAGUK) family and is highly expressed in the brain and in glomerular podocytes in the kidney, where it plays a pivotal role in assembling signaling complexes at synaptic junctions and within the slit diaphragm of the glomerular filtration barrier[1][2][5]. MAGI-2 directly interacts with nephrin and other junctional proteins, and is necessary for maintaining podocyte structure and preventing proteinuria and glomerulosclerosis[2][3]. Mutations or downregulation of MAGI-2 are associated with hereditary and steroid-resistant nephrotic syndrome as well as certain cancers, and its expression level serves as a sensitive marker for podocyte injury in both experimental models and human kidney disease[2][3][5].

Other names

Membrane-associated guanylate kinase inverted 2MAGI2Atrophin-1-interacting protein 1 (AIP-1)S-SCAMARIP1