Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (MAGI3)

MAGI3 is a multidomain scaffold protein of the membrane-associated guanylate kinase family, notable for its PDZ, WW, and guanylate kinase domains[1][2][3][4][5]. It acts at cell-cell junctions and membrane sites to organize signaling complexes, controlling processes such as cell adhesion, polarity, and signal transduction. MAGI3 interacts with important proteins including PTEN, receptor tyrosine phosphatases (e.g., PTPRB), Frizzled receptors, and lysophosphatidic acid receptor 2, thereby modulating diverse pathways (e.g., Akt, JNK, ERK, RhoA) relevant to cell migration, immune function, and cell proliferation[1][2][3][4][5][6]. Dysregulation of MAGI3—by genetic variation, viral targeting (high-risk HPV E6, influenza NS1), or aberrant mRNA processing—has been linked to multiple disease processes, especially cancer, autoimmune disorders, and epithelial barrier dysfunction[1][2]. It does not have GMP kinase enzymatic activity but is sometimes annotated as such due to domain homology[2][4]. No approved drugs currently target MAGI3 directly, but its expression and functional status influence disease biology and may aid in biomarker research.

Other names

MAGI3MAGI-3Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3Membrane-associated guanylate kinase inverted 3Membrane-associated guanylate kinase-related 3DJ730K3.2KIAA1634dJ730K3.24732496O19Rik (mouse)6530407C02Rik (mouse)

null (No direct mechanism of action for drugs targeting MAGI3 is documented in the search results.)