Membrane-associated phosphatidylinositol transfer protein 1 (PITPNM1)

Membrane-associated phosphatidylinositol transfer protein 1 (PITPNM1) is a cytosolic lipid transfer protein that catalyzes the transfer of phosphatidylinositol between membranes and binds phosphatidylinositol, phosphatidic acid, and phosphatidylcholine (affinity: PI > PA > PC)[2][9]. It is essential for maintaining normal levels of diacylglycerol in the Golgi apparatus, proper structure of the endoplasmic reticulum and Golgi, completion of cytokinesis, and protein export from organelles. PITPNM1 has homology to the Drosophila retinal degeneration B protein and plays key regulatory roles in cytoskeleton remodeling and calcium ion binding. Variants in this gene are associated with retinal degeneration and cone-rod dystrophy, and the protein participates in critical glycerophospholipid metabolism and signaling pathways[1][2][3][9].

Other names

PITPNM1NIR2PITPNMDRES9RDGBRDGB1RDGBARDGBA1Rd9PITPnm 1NIR-2Pyk2 N-terminal domain-interacting receptor 2PYK2 N-terminal domain-interacting receptor 2Drosophila retinal degeneration B homologRetinal degeneration B alpha 1Phosphatidylinositol transfer protein, membrane associated 1Phosphatidylinositol transfer protein, membrane-associated 1

Lipid transfer inhibitors (theoretical); Modulators of phosphoinositide signaling pathways (theoretical/experimental)