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Target intelligence / Profile preview
Membrane-associated Rapid Response Steroid-binding Receptor (1,25D3-MARRS)
- Target
- 1,25D3-MARRS
- Molecular classification
- Receptor, Protein disulfide isomerase
01
Overview
The membrane-associated rapid response steroid-binding receptor (1,25D3-MARRS), also known as PDIA3 or ERp57, is a non-classical vitamin D receptor that mediates rapid cellular responses to 1,25(OH)2D3. It is involved in calcium uptake, cell proliferation, and migration, particularly in cancer cells. It signals through kinase activation and regulation of calcium channels, distinct from the classical nuclear vitamin D receptor (VDR).
- Other names
- PDIA3ERp57
02
Mechanism of action
Non-genomic signal transduction via kinases (Src, PI3K), regulation of calcium channels.
03
Biological functions
Signal transductionCalcium uptakeCell proliferationCell migrationPhosphate uptakeProtein folding
04
Disease associations
Cancer
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