Membrane-associated ring-CH-type finger protein 7 (MARCHF7)

Membrane-associated ring-CH-type finger protein 7 (MARCHF7) is a membrane-bound E3 ubiquitin ligase enzyme implicated in the addition of ubiquitin to substrate proteins, a process essential for targeting proteins for degradation or for directing them to specific membrane compartments. MARCHF7 modulates processes such as autophagy by ubiquitinating proteins like ATG14, regulates T-cell proliferation, and contributes to the downregulation of inflammasome activity via ubiquitin-mediated degradation. High levels of expression are seen in various tissues, and dysfunction of this protein is associated with diseases of immune regulation and may contribute to cancer and other pathologies

Other names

MARCH7MARCH-VIIRNF177AXOTAxotrophinMembrane-associated RING finger protein 7E3 ubiquitin-protein ligase MARCHF7RING finger protein 177RING-type E3 ubiquitin transferase MARCHF7Membrane-associated ring finger (C3HC4) 7E3 ubiquitin protein ligase MARCHF7

Inhibition or modulation of E3 ubiquitin ligase activity, affecting protein stability and signaling; Modulation of autophagy through ubiquitination of autophagy-related proteins (e.g., ATG14)