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Target intelligence / Profile preview
Membrane-bound Immunoglobulin E (mIgE)
- Target
- mIgE
- Molecular classification
- B cell receptor, Immunoglobulin, Antibody
01
Overview
Membrane-bound Immunoglobulin E (mIgE) is a form of the IgE antibody anchored to the surface of B cells, functioning as part of the B cell antigen receptor (BCR) complex. It serves as an antigen-specific receptor, triggering B cell activation, proliferation, and differentiation into plasma cells upon antigen binding. Dysregulation or overproduction can contribute to atopic disorders.
02
Mechanism of action
N/A
03
Biological functions
Antigen recognitionB cell activationHumoral immune responseB cell proliferationB cell differentiation
04
Disease associations
Allergic rhinitisAsthmaFood allergiesAtopic dermatitisUrticariaSystemic anaphylaxisAtopic disorders
05
Safety considerations
Dysregulation can lead to atopic disordersOverproduction can exacerbate allergic reactions
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