Target intelligence / Profile preview

Dehydropeptidase 1 (DPEP1)

Target: DPEP1
Molecular classification: Enzyme, Metalloproteinase

Overview

Dehydropeptidase 1 (DPEP1), also known as renal dipeptidase or membrane dipeptidase, is a zinc-dependent metalloproteinase primarily expressed in the kidney. It plays a key role in hydrolyzing a wide range of dipeptides and is involved in the metabolism of certain antibiotics and bioactive peptides. DPEP1 is upregulated in some cancers and promotes tumor cell adhesion and invasion.

Other names: Renal dipeptidaseMembrane dipeptidase

Mechanism of action

Inhibition of DPEP1 enzymatic activity

Biological functions

Hydrolysis of dipeptidesBeta-lactam hydrolysisLeukotriene metabolismRegulation of cell adhesionRegulation of cell invasion

Disease associations

CancerInflammation

Safety considerations

Degradation of beta-lactam antibiotics

Interacting drugs

Imipenem

1 more in the full profile.

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