Membrane Energetics in Mycobacterium tuberculosis

Membrane energetics in *Mycobacterium tuberculosis* refers to the processes by which the bacterium maintains and utilizes its transmembrane electrochemical gradients, primarily for ATP synthesis, transport, and survival under various stress conditions. This system is crucial for bacterial viability and persistence, making it a promising target for novel anti-tuberculosis therapies. The proton motive force (PMF), generated by the electron transport chain, is a key component, and its disruption can lead to bacterial death, especially in persistent forms. Targeting membrane energetics can also synergistically enhance the efficacy of first-line TB drugs.

Other names

Mycobacterial membrane energeticsM. tuberculosis energy metabolismProton motive force in M. tuberculosisElectron transport chain in M. tuberculosis

Disruption of the proton motive force, inhibition of ATP synthase, interference with electron transport chain components, potentiation of existing anti-TB drugs