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Target intelligence / Profile preview
Membrane metallo-endopeptidase-like 1 (MMEL1)
- Target
- MMEL1
- Molecular classification
- Enzyme, Metalloprotease, Type II transmembrane protein
01
Overview
Membrane metallo-endopeptidase-like 1 (MMEL1) is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. It is a type II transmembrane protein that may also exist in a secreted form, and is mainly expressed in testis, with limited expression in brain, kidney, and heart. MMEL1 acts as a metalloprotease involved in sperm function, potentially by modulating the processes of fertilization and early embryonic development. The broader NEP family, to which MMEL1 belongs, is implicated in pain perception, arterial pressure regulation, phosphate metabolism, and homeostasis[1][2][3][4][5][6].
- Other names
- MMEL2NEP2NEPIINL1NL2SEPmembrane metalloendopeptidase like 1membrane metallo-endopeptidase-like 1Neprilysin IINeprilysin-2soluble secreted endopeptidasezinc metallopeptidase
02
Biological functions
Sperm functionFertilization modulationEarly embryonic developmentPain perception (family function)Arterial pressure regulation (family function)Phosphate metabolism and homeostasis (family function)
03
Disease associations
Neurodegenerative disease (based on family, such as NEP involvement)Potential roles in reproduction disordersOther (direct clinical roles specifically for MMEL1 are not well-established in the provided sources)
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