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Membrane Metalloendopeptidase (MME)
- Target
- MME
- Molecular classification
- Enzyme, Metalloprotease, Type II integral membrane protein
01
Overview
Membrane metalloendopeptidase is a multifunctional enzyme critical for neuroendocrine regulation and serves as both a diagnostic biomarker and potential therapeutic target across diverse diseases including heart failure, neurodegeneration such as Alzheimer's disease, autoimmune disorders like SLE—and various malignancies where its role can be either tumor-suppressive or oncogenic depending on cellular context.
- Other names
- NeprilysinNeutral endopeptidase (NEP)CD10CALLA
02
Mechanism of action
Hydrolyzes peptide bonds on the amino side of hydrophobic residues, inactivating peptide hormones.
03
Biological functions
Peptide hormone degradationNatriuretic peptide metabolismAmyloid beta peptide degradationRegulation of cardiovascular functionPain signaling modulationFluid balance regulation
04
Disease associations
Alzheimer's DiseaseHeart FailureAcute Lymphoblastic LeukemiaVarious CancersSystemic Lupus ErythematosusCardiac Disorders
05
Safety considerations
Potential for off-target effects due to broad substrate specificityVariations in drug response due to genetic polymorphisms affecting MME activityComplex and context-dependent role in cancer, requiring careful consideration of tissue-specific effects
06
Biomarkers
CD10/CALLA expression in ALLMME activity in Alzheimer's DiseaseMME expression levels in various cancers
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