Membrane palmitoylated protein 1 (MPP1)

Membrane palmitoylated protein 1 (MPP1) is a prototypical member of the membrane-associated guanylate kinase (MAGUK) protein family and serves as a highly palmitoylated peripheral membrane scaffold protein. Initially identified in erythrocytes, MPP1 forms a ternary complex with protein 4.1R and glycophorin C, playing a critical part in attaching the cytoskeleton to the plasma membrane and stabilizing cell shape. It interacts with flotillin raft marker proteins, organizing and stabilizing plasma membrane lipid raft domains, and is required for raft-dependent signal transduction (e.g., insulin receptor signaling). MPP1 also plays essential roles in maintaining apico-basal cell polarity (notably in the retina and auditory hair cells), regulation of actin polymerization, and the organization of cellular architecture. In immune cells, especially neutrophils, MPP1 is a key regulator of polarity and migration by modulating Akt phosphorylation. Genetic studies reveal that loss of MPP1 impairs cell polarity and directional movement, particularly affecting neutrophil chemotaxis. While MPP1 is not a current drug target, mutations or disruptions in its function may contribute to immune, developmental, and neoplastic diseases[1][3][5][7].

Other names

55 kDa erythrocyte membrane proteinDXS552EEMP55p55PEMPmembrane palmitoylated protein 1AAG12MRG1aging-associated gene 12migration-related gene 1palmitoylated erythrocyte membrane protein