Membrane potential of cancer cell (Vm (when context specifies cancer cell))

Cancer cell membrane potential is an electrical property defined by the difference in electric potential across the plasma membrane in cancer cells, primarily governed by ion channels and transporters. Cancer cells display a depolarized resting membrane potential compared to normal cells, which is associated with increased proliferation, altered cell cycle progression, metastasis, and resistance to apoptosis. Vm fluctuations are not static but dynamically regulate several key cancer phenotypes, including migration, stemness, and cell division. Modulating the membrane potential, particularly through targeted ion channel inhibition or activation, is an emerging therapeutic strategy, though it presents substantial challenges due to the non-specific nature of the underlying mechanisms and potential for systemic side effects.

Other names

Cancer cell resting membrane potentialVm in cancer cellsPlasma membrane potential in tumor cells

Ion channel blockade (e.g., sodium, potassium, calcium channels—alter Vm to arrest proliferation/migration). Modulation of ion channel expression/activity to induce hyperpolarization or depolarization, influencing cell cycle or apoptosis. Pulsed electric fields to manipulate Vm.