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Membrane Progesterone Receptor Alpha (mPRα)
- Target
- mPRα
- Molecular classification
- Progestin and adipoQ receptor (PAQR), Membrane receptor, G protein-coupled receptor
01
Overview
Membrane progesterone receptor alpha (mPRα/PAQR7) is a plasma membrane steroid hormone receptor mediating rapid non-genomic actions of progesterone through G protein-coupled signaling. It plays crucial roles across reproductive physiology and has emerging significance as a biomarker or therapeutic target—especially where classical nuclear PRs are absent or inactive—in cancers such as triple-negative breast cancer and lung adenocarcinoma.
- Other names
- PAQR7Membrane progestin receptor alpha
02
Mechanism of action
G protein-coupled signaling; Primarily coupled to inhibitory G proteins (Gi), leading to downregulation of adenylyl cyclase activity.
03
Biological functions
Signal transductionOocyte maturationSperm hypermotilityRegulation of cell proliferationEpithelial-mesenchymal transition (EMT)Modulation of GABA_A receptors
04
Disease associations
CancerBreast cancerLung adenocarcinoma
05
Safety considerations
Potential for off-target effects due to broad expression across tissues.Complex signaling pathways may lead to unpredictable downstream effects.
06
Interacting drugs
Progesterone
1 more in the full profile.
07
Biomarkers
mPRα expression levels in breast cancermPRα expression levels in lung adenocarcinoma
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