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Membrane Progesterone Receptor Beta (mPRβ)
- Target
- mPRβ
- Molecular classification
- Progestin and adipoQ receptor family (PAQR), Membrane receptor
01
Overview
Membrane progesterone receptor beta (mPRβ), also known as PAQR8, is a member of the membrane progesterone receptor family. It mediates rapid, non-genomic actions of progesterone, distinct from those mediated by classical nuclear progesterone receptors. mPRβ plays a role in neurite outgrowth and respiratory control, particularly in brainstem neurons involved in ventilatory chemoreflexes. It binds progesterone with high affinity and signals through pathways independent of canonical G protein-coupled receptor signaling.
- Other names
- PAQR8
02
Mechanism of action
Binds progesterone, leading to non-genomic signaling effects, including ERK phosphorylation and modulation of neuronal activity.
03
Biological functions
Signal transductionNeurite outgrowthRespiratory controlModulation of neuronal growth/differentiationRegulation of respiratory neural circuitsReproductive tissue function
04
Interacting drugs
Progesterone
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