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Membrane Progesterone Receptor Delta (mPRδ)
- Target
- mPRδ
- Molecular classification
- Receptor, Progestin and adipoQ receptor family (PAQR), G protein-coupled receptor (GPCR)-like
01
Overview
Membrane progesterone receptor delta (mPRδ) is a member of the membrane progesterone receptor (mPR) family, also known as progestin and adipoQ receptor family members (PAQRs). It mediates rapid, non-genomic actions of progesterone. mPRδ is encoded by the PAQR6 gene and is primarily located at the plasma membrane. Structurally, it is predicted to have seven transmembrane domains, similar to G protein-coupled receptors (GPCRs). Upon activation by progesterone, mPRδ couples to G proteins, leading to modulation of second messenger systems such as cAMP levels. It is widely distributed across vertebrate tissues and participates in diverse functions including reproductive processes, neuroprotection, behavior regulation, and immune function.
- Other names
- PAQR6Membrane progestin receptor delta
02
Mechanism of action
Agonist; binds to mPRδ and activates G protein signaling pathways, leading to rapid non-genomic effects.
03
Biological functions
Signal transductionReproductive processesNeuroprotectionRegulation of behaviorRespiratory controlOlfactory response modulationNerve regenerationImmune function regulationVascular protection
04
Disease associations
Potentially implicated in various diseases due to broad tissue expression; specific roles under investigation
05
Interacting drugs
Progesterone
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