Membrane repair

Membrane repair refers to the collection of cellular mechanisms that rapidly reseal disruptions in the plasma membrane caused by mechanical, chemical, or pathogenic injury[1][2][3][4][5]. These mechanisms include exocytosis-mediated addition of membrane, endocytosis-mediated removal of damaged areas, shedding of membrane vesicles, and protein-driven patching and cytoskeletal remodeling. The process involves proteins such as acid sphingomyelinase, MG53, annexins, calpains, dysferlin, and synaptotagmins[1][3][4][6]. Membrane repair is essential for the survival of all eukaryotic cells and is particularly important in tissues with high mechanical or metabolic stress, such as skeletal muscle and heart. Defects in membrane repair are implicated in diseases such as muscular dystrophies, cardiomyopathies, neurodegenerative disorders, and can influence host response in infections and cancer[1][2][3]. Membrane repair is therefore not a druggable target molecule or receptor, but rather a cellular process involving multiple proteins, some of which can serve as molecular targets. If you are seeking information on a specific membrane repair protein (e.g., MG53, dysferlin, annexins), please provide the protein name for structured information.

Other names

plasma membrane repaircell membrane repairmembrane resealingcellular wound healing

null as a process; for drugs modulating repair proteins: inhibition or activation of exocytosis, endocytosis, or membrane fusion machinery, etc.