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Membrane Spanning 4-Domains Subfamily A Member 1 (None)
- Target
- None
- Molecular classification
- Membrane-spanning 4-domains subfamily A (MS4A), Transmembrane protein
01
Overview
CD20 is a non-glycosylated transmembrane protein expressed on B lymphocytes from the pre-B cell stage through mature stages, but not on early pro-B cells or terminally differentiated plasma cells. It plays a role in calcium flux and B-cell receptor signaling and is a major therapeutic target for monoclonal antibody therapies in hematological malignancies and autoimmune diseases.
- Other names
- CD20B-lymphocyte antigen CD20B-lymphocyte surface antigen B1Leukocyte surface antigen Leu-16
02
Mechanism of action
Antibody binding induces clustering/oligomerization that recruits complement proteins leading to targeted lysis of B-cells via complement-dependent cytotoxicity.
03
Biological functions
Modulates Ca²⁺ fluxB-cell receptor (BCR) signalingImmune response
04
Disease associations
Non-Hodgkin lymphomaChronic lymphocytic leukemiaAutoimmune diseases
05
Interacting drugs
Rituximab
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