Target intelligence / Profile preview

Membrane-spanning 4-domains subfamily A member 10 (MS4A10)

Target
MS4A10
Molecular classification
Tetraspanin, Ion channel, Membrane protein, Other (MS4A protein superfamily)
01

Overview

Membrane-spanning 4-domains subfamily A member 10 (MS4A10) is part of the MS4A (membrane-spanning 4-domain, subfamily A) superfamily, which consists of tetraspanin-like membrane proteins characterized by four transmembrane domains[1]. MS4A proteins are selectively expressed on the surfaces of various immune cells and often participate in calcium ion channel activity and immune signaling modulation, sometimes acting as signal modulators or chaperones for immune receptors. MS4A family members have been implicated in physiological processes such as signal transduction, cell activation, and immune cell differentiation. Genetic and functional studies associate the MS4A family with pathologies including cancer, autoimmunity, infection, allergy, and neurodegenerative disease, though specific high-confidence information on the precise functions or drug interactions involving MS4A10 is limited in the current literature[1]. **Notes:** - There is limited information specific to MS4A10 as an individual protein, especially regarding therapeutic drugs, mechanism of action, or safety concerns. Most functional and disease role data are inferred from general properties of the MS4A protein family[1]. - No direct evidence was found for drugs or biologics directly targeting MS4A10, nor its widespread use as a standalone diagnostic or therapeutic biomarker at this time[1].

Other names
CD20 antigen-like 7CD20L7MS4A9membrane-spanning 4-domains, subfamily A, member 10
02

Biological functions

Ion transport (primarily calcium)Modulation of immune receptor signalingSignal transductionRegulation of cell activation and differentiation
03

Disease associations

CancerNeurodegenerative disease (such as Alzheimer’s disease)Autoimmune diseaseInfectionAllergy
04

Biomarkers

Possible biomarker for some immune-related diseases and cancers (by analogy to other MS4A family members; specific data for MS4A10 limited)[1]

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