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Membrane-spanning 4-domains subfamily A member 15 (MS4A15)
- Target
- MS4A15
- Molecular classification
- Tetraspanin, Transmembrane protein, Membrane protein, Other
01
Overview
Membrane-spanning 4-domains subfamily A member 15 (MS4A15) is a tetraspanin transmembrane protein localized to the endoplasmic reticulum. It regulates cellular susceptibility to ferroptosis by depleting ER luminal calcium stores and reprogramming lipid metabolism, increasing the abundance of monounsaturated and ether phospholipids that resist oxidative damage. This mechanism provides protection from ferroptosis and supports metabolic adaptation under nutrient stress. MS4A15 is overexpressed in several cancers (notably ovarian cancer), where its high expression is correlated with increased tumor cell proliferation, metabolic reprogramming, and poorer prognosis. Its central role in ferroptosis resistance and metabolic adaptation makes it a promising emerging therapeutic target in cancer biology[1][3][4][7].
- Other names
- membrane-spanning 4-domains, subfamily A, member 15M4A15_HUMAN
02
Mechanism of action
Inhibition of ferroptosis through alteration of endoplasmic reticulum calcium homeostasis; Depletion of ER luminal Ca2+ leading to remodeling of membrane phospholipids towards ferroptosis-resistant species
03
Biological functions
Regulation of ferroptosis (iron-dependent cell death)Calcium signaling modulationCell surface receptor signaling pathwayCell proliferationRegulation of cell metabolismLipid remodeling
04
Disease associations
Cancer (including ovarian cancer, lung adenocarcinoma, and others)Ferroptosis-associated diseasesOther
05
Biomarkers
Overexpression may serve as a prognostic biomarker for poor outcome in ovarian cancer and potentially other solid tumors
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