Membrane-spanning 4-domains subfamily A member 6A (MS4A6A)

MS4A6A (Membrane-spanning 4-domains subfamily A member 6A) is a member of the MS4A gene family, defined by four transmembrane domains, and is primarily expressed in microglia in the brain. It acts as a regulator of microglial immune function, participates in signal transduction within multimeric receptor complexes, and modulates inflammatory responses. MS4A6A genetic variants are implicated in the risk for Alzheimer’s disease and other neurodegenerative disorders through their influence on amyloid-beta clearance and inflammatory pathways. While no drugs currently target MS4A6A directly, understanding its biology supports ongoing research into microglia and neurodegenerative disease therapy.

Other names

Membrane-spanning 4-domains subfamily A member 6AMS4A6A4SPAN3CD20L3MS4A6CDA01MSTP090Four-span transmembrane protein 3CD20 antigen-like 34SPAN3.14SPAN3.2membrane-spanning 4-domains subfamily A member 6ACD20-like precursorHAIRB-isoMS4A6A-polymorphMST090

For potential modulators: Regulation of microglia activation, inflammation suppression (JAK2/NF-κB signaling), and enhancement of amyloid-beta phagocytosis. Targeting transcription/expression levels via SNPs that modulate MS4A6A abundance, which correlates to AD risk and biomarker changes.