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Membrane Type 1-Matrix Metalloprotease (MT1-MMP)
- Target
- MT1-MMP
- Molecular classification
- Enzyme, Metalloproteinase, Matrix Metalloproteinase, Type I transmembrane protein
01
Overview
Membrane Type 1-Matrix Metalloprotease (MT1-MMP), also known as MMP14, is a zinc-dependent type I transmembrane metalloproteinase and a member of the matrix metalloproteinase (MMP) family. It plays a crucial role in extracellular matrix (ECM) remodeling by degrading various ECM components and activating other proteases. MT1-MMP is essential for cell migration, invasion, and angiogenesis, making it an attractive target for anti-cancer therapies. Elevated expression is correlated with poor prognosis in several cancers. It is also implicated in cardiovascular disease and arthritis.
- Other names
- MMP14MTMMP1MT-MMP 1WNCHRS[8]
02
Mechanism of action
Inhibition of MT1-MMP activity to prevent ECM degradation, tumor invasion, and angiogenesis.
03
Biological functions
Extracellular matrix remodelingProteolysisCell migrationCell invasionPro-MMP2 activationTissue homeostasisAngiogenesis
04
Disease associations
CancerCardiovascular diseaseArthritis
05
Safety considerations
Potential for off-target effects due to broad substrate specificity.Disruption of normal tissue remodeling processes.
06
Biomarkers
Biomarker for aggressive tumors
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