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Target intelligence / Profile preview
Menin (MEN1)
- Target
- MEN1
- Molecular classification
- Scaffold protein, Tumor suppressor, Transcription factor regulator, Chromatin remodeling factor, Epigenetic regulator
01
Overview
Menin is a nuclear scaffold protein encoded by the MEN1 gene. It functions as a regulator of gene transcription, chromatin remodeling, and epigenetic control of gene expression. Menin is best known for its role as a tumor suppressor and its association with multiple endocrine neoplasia type 1 (MEN-1) syndrome. Loss-of-function mutations in MEN1 lead to disrupted cell cycle control mechanisms and increased risk of tumor formation, especially within endocrine tissues.
- Other names
- Multiple Endocrine Neoplasia Type 1 ProteinMEN1 protein
02
Mechanism of action
N/A
03
Biological functions
Tumor suppressionChromatin remodelingTranscriptional regulationHistone modificationEpigenetic gene regulationCell cycle controlDNA repair/apoptosis regulationTGFB1-mediated signaling
04
Disease associations
Multiple Endocrine Neoplasia Type I (MEN-I)Parathyroid tumorsPituitary adenomasPancreatic neuroendocrine tumorsGastrinomaAdrenocortical cancersPrimary macronodular adrenal hyperplasiaCancer
05
Safety considerations
Targeting menin directly may have broad effects on transcription and chromatin remodeling, leading to potential off-target effects.Inhibition of menin function can disrupt normal cell cycle control and increase the risk of tumor formation in certain tissues.
06
Biomarkers
MEN1 mutations (diagnostic and prognostic in MEN-I)Menin protein expression levels (potential biomarker for tumor aggressiveness)
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