Meningioma (disrupted in balanced translocation) 1 proto-oncogene, transcriptional regulator (MN1)

The MN1 proto-oncogene, transcriptional regulator (MN1), encodes a protein that serves as a transcriptional co-regulator modulating gene expression by interacting with other transcription factors and chromatin remodeling complexes. MN1 is disrupted in certain chromosomal translocations, notably in meningioma and various hematological malignancies such as acute myeloid leukemia, where it participates in fusion genes or is overexpressed. Its normal function involves regulation of genes essential for skull and brain development as well as hematopoiesis. Pathogenic variants, particularly those truncating the C-terminal region, are associated with neurodevelopmental syndrome characterized by intellectual disability, craniofacial anomalies, and distinctive brain malformation. MN1 is not a current direct therapeutic target and no drugs are known to interact specifically with MN1, but its expression and gene status serve as important biomarkers, especially in the context of prognosis for leukemias.

Other names

MGCRMGCR1MGCR1-PENprobable tumor suppressor protein MN1CEBALIDmeningioma chromosome region 1meningioma (translocation balanced)transcriptional activator MN1dJ353E16.2