Meningococcal Protein (N/A)

Meningococcal proteins, such as Outer Membrane Protein Complex (OMPC) and Class 2 Porin, are used as carrier proteins in conjugate vaccines. They convert T-cell independent polysaccharide antigens into T-cell dependent forms, enhancing immunogenicity and enabling effective immune memory formation. While OMPC was used in some early Hib conjugate vaccines, currently licensed meningococcal conjugate vaccines primarily utilize CRM197, TT, or DT due to manufacturing consistency and safety profiles. The choice of carrier protein is critical due to potential effects on overall vaccine efficacy and interactions with other co-administered vaccines.

Other names

Neisseria meningitidis Outer Membrane Protein Complex (OMPC)Class 2 Porin ProteinMeningococcal-derived carrier protein

Acts as a carrier to convert polysaccharide antigens into T-cell dependent antigens, thereby enhancing immunogenicity and enabling effective immune memory formation.