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Meniscal tissue replacement refers to the broad array of **surgical procedures** (such as meniscal allograft transplantation), **synthetic or natural scaffolds**, and **tissue engineering constructs** used to replace or repair a damaged meniscus in the knee. The approaches include transplanting cadaveric meniscus tissue (allograft), using biomaterial scaffolds (e.g., collagen, silk, hyaluronic acid), or 3D-printed constructs seeded with cells or growth factors. The primary goal is to restore biomechanical function and stability to the knee, protecting the articular cartilage and preventing or delaying osteoarthritis. These interventions are distinct from traditional drug targets because they are structural/biomechanical rather than molecular entities. Meniscal tissue replacement is an **interventional strategy**, not a molecular or cellular target.
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