Meprin A subunit alpha pseudogene

Meprin A subunit alpha pseudogene (ENSG00000284611) is a pseudogene related to the functional meprin A subunit alpha gene (MEP1A), which encodes one of the subunits of the meprin A oligomeric metalloprotease complex[1][2][3][4][9]. Pseudogenes are genomic DNA sequences similar to normal genes but typically nonfunctional; they do not encode active proteins due to mutations or lack of regulatory elements. Meprin A subunit alpha pseudogenes have been annotated in the human genome (for example, *MEP1AP4*)[7], but do not produce protein and have no known role as drug targets, enzymes, receptors, or biomarkers. Therefore, ENSG00000284611 is not a therapeutic target and should not be used as such. The functional protein-coding version is *MEP1A* (meprin A subunit alpha), which is a metalloprotease involved in proteolysis and some disease processes like inflammatory bowel disease[1][3][4][9]. Pseudogenes like ENSG00000284611 differ from functional genes in that they do not produce an active protein product and hence lack biological functions or clinical roles[7]. There are no approved drugs, disease associations, or mechanisms of action for this pseudogene. If you intended the functional meprin A subunit alpha protein (MEP1A, ENSG00000112818), please clarify, as this may yield therapeutic relevance.

Other names

Meprin A alpha pseudogeneMEP1A pseudogenemeprin A subunit alpha pseudogene 4