Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
MER Proto-Oncogene Tyrosine Kinase (MerTK)
- Target
- MerTK
- Molecular classification
- Receptor Tyrosine Kinase, TYRO3/AXL/MER (TAM) receptor family
01
Overview
MerTK is a receptor tyrosine kinase that belongs to the TAM family. It plays a crucial role in signal transduction, phagocytosis/efferocytosis, and immune regulation. It is essential for the clearance of apoptotic cells and modulating cytokine production, thereby preventing systemic autoimmune diseases. It has oncogenic roles in cancer, promoting angiogenesis, migration/invasion, and cell survival, making it a therapeutic target. However, its anti-inflammatory functions must be considered to avoid exacerbating inflammation-associated cancers.
- Other names
- c-mer proto-oncogene tyrosine kinaseTyrosine-protein kinase Mer
02
Mechanism of action
Ligand binding induces autophosphorylation, creating docking sites for downstream signaling molecules, activating pathways like MAPK1/2, FAK/PTK2, and RAC1.
03
Biological functions
Signal transductionPhagocytosisEfferocytosisImmune regulationCell survivalMigrationDifferentiationPlatelet function
04
Disease associations
Retinitis PigmentosaCancerAutoimmune Disorders
05
Safety considerations
Therapeutic inhibition must be balanced against its critical anti-inflammatory functions.Loss of function can exacerbate inflammation-associated cancers.Impaired clearance of apoptotic neutrophils.Increased proinflammatory cytokines.
Beyond the preview
Go deeper on MER Proto-Oncogene Tyrosine Kinase (MerTK).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on MER Proto-Oncogene Tyrosine Kinase (MerTK).