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Target intelligence / Profile preview
Mer receptor tyrosine kinase (MerTK)
- Target
- MerTK
- Molecular classification
- Receptor tyrosine kinase, TAM family receptor
01
Overview
MerTK is a receptor tyrosine kinase belonging to the TAM family. It plays a crucial role in efferocytosis, platelet function, and immune regulation. As an innate immune checkpoint, it is often exploited by cancer cells to suppress anti-tumor immunity, making it a target for cancer immunotherapy. Ligands include GAS6 and PROS1, which induce receptor dimerization and autophosphorylation, activating downstream signaling pathways like MAPK/ERK and PI3K/AKT.
- Other names
- c-mer proto-oncogene tyrosine kinaseProto-oncogene tyrosine-protein kinase MER
02
Mechanism of action
Inhibition of MerTK kinase activity, blocking downstream signaling pathways
03
Biological functions
EfferocytosisPlatelet functionCytoskeleton reorganizationImmune regulationPhagocytosis
04
Disease associations
Retinitis pigmentosaCancerAutoimmune diseasesInflammatory diseases
05
Safety considerations
Potential for off-target effects due to kinase similarityImmune-related adverse eventsThrombocytopenia
06
Biomarkers
MERTK expression level in tumor tissueGAS6 levels
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