Target intelligence / Profile preview

MER Tyrosine Kinase

Molecular classification: Receptor, Enzyme, Tyrosine kinase, Receptor tyrosine kinase, TAM receptor tyrosine kinase family

Overview

MER Tyrosine Kinase (MERTK) is a receptor tyrosine kinase that regulates various physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells. Mutations in MERTK are associated with retinitis pigmentosa, while overexpression or aberrant activation has been implicated in various cancers.

Other names: MERTKMERc-mer proto-oncogene tyrosine kinase

Mechanism of action

Pharmacological inhibition or targeted degradation of MerTK.

Biological functions

Cell survivalCell migrationCell differentiationPhagocytosis of apoptotic cells (efferocytosis)Innate immune checkpoint regulationAnti-tumor immune response modulationImmune tolerance

Disease associations

Retinitis pigmentosaCancer

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