MER1 repeat containing imprinted transcript 1 (MIMT1)

MER1 repeat containing imprinted transcript 1 (MIMT1) is a long intergenic non-coding RNA gene located on chromosome 19 in humans[1][7]. MIMT1 undergoes alternative splicing, resulting in at least two transcript variants, and does not encode a protein[1][5]. The gene is imprinted and may regulate the expression of neighboring genes, notably PEG3 and USP29, through a bidirectional promoter mechanism[5]. Microdeletions that disrupt MIMT1 expression are associated with developmental abnormalities in cattle, specifically stillbirth and compromised placental function, likely due to altered imprinting and gene regulation[5]. In humans, MIMT1 is significantly down-regulated in colorectal cancer, suggesting a potential role as a tumor suppressor lncRNA, though its mechanistic functions remain to be confirmed[2]. As a lncRNA, MIMT1 participates in transcriptional and epigenetic regulation but is currently not regarded as a standard therapeutic target, nor does it have known interacting drugs or established mechanisms for pharmacological intervention[1][7].

Other names

MIM1NCRNA00067LINC00067non-protein coding RNA 67long intergenic non-protein coding RNA 67