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Target intelligence / Profile preview
Merkel Cell Polyomavirus Large and Small Tumor Antigens (MCPyV LT/sT)
- Target
- MCPyV LT/sT
- Molecular classification
- Viral Oncoprotein, Tumor Antigen
01
Overview
Merkel cell polyomavirus (MCPyV) large T antigen (LT) and small T antigen (sT) are viral oncoproteins expressed in Merkel cell carcinoma (MCC). LT disrupts Rb function to promote cell cycle progression, while sT enhances oncogenesis and inhibits immune responses. Targeting these antigens is a promising therapeutic strategy for MCC.
- Other names
- MCPyV Large T AntigenMCPyV Small T AntigenLTsT
02
Mechanism of action
Inhibition of Rb, Interference with NF-κB signaling, Stabilization of c-MYC/cyclin E
03
Biological functions
Cell cycle regulationCell proliferationImmune evasionOncogenesisTranscriptional regulation
04
Disease associations
Merkel Cell Carcinoma (MCC)Cancer
05
Safety considerations
Specificity to tumor cells expressing the antigensPotential off-target effects if targeting cellular proteins interacting with LT/sT
06
Biomarkers
MCPyV DNA presence in tumor tissueLT/sT expression levels
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