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Merozoite Surface Protein 3

Molecular classification: Protein

Overview

Merozoite Surface Protein 3 is an exposed soluble protein complexed on P. falciparum’s invasive stage. It binds heme via amyloid-like structures, interacts closely with other major merozoite antigens through its N-terminal domain, serves as an important target for host immune responses—especially at its C terminus—and remains under active investigation both functionally and as part of next-generation malaria vaccines.

Biological functions

Heme bindingErythrocyte invasionImmune evasionImmune modulation

Disease associations

Infection

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