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Target intelligence / Profile preview
Mesenchymal Epithelial Transition Factor Receptor Kinase (MET)
- Target
- MET
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
The mesenchymal epithelial transition factor receptor kinase (MET), also known as c-Met, is a receptor tyrosine kinase that plays a crucial role in cellular processes such as cell growth, proliferation, motility, survival, morphogenesis, and tissue regeneration. Aberrant activation of MET is implicated in cancer progression and metastasis. MET is activated by its ligand, hepatocyte growth factor (HGF), leading to downstream signaling through the PI3K/Akt, MAPK, and STAT pathways. Therapeutic strategies targeting MET include tyrosine kinase inhibitors and monoclonal antibodies against HGF or MET.
- Other names
- c-MetHepatocyte Growth Factor Receptor
02
Mechanism of action
Inhibition of MET kinase activity or blocking HGF/MET interaction, disrupting downstream signaling pathways such as PI3K/Akt, MAPK, and STAT.
03
Biological functions
Cell growthCell proliferationCell motilityCell survivalTissue repairWound healingEmbryonic DevelopmentMorphogenesis
04
Disease associations
CancerMetastasis
05
Safety considerations
On-target toxicityResistance developmentOff-target effects
06
Interacting drugs
Tyrosine kinase inhibitors
2 more in the full profile.
07
Biomarkers
MET expression levelsMET mutationsHGF levels
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