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Target intelligence / Profile preview
Mesenchymal Epithelial Transition Factor Receptor Tyrosine Kinase (MET)
- Target
- MET
- Molecular classification
- Receptor Tyrosine Kinase, Receptor
01
Overview
MET is a receptor tyrosine kinase that plays a central role in cellular processes such as proliferation, survival, motility, morphogenesis, and angiogenesis. It is the product of the MET proto-oncogene and is primarily expressed on epithelial cells. Its natural ligand is hepatocyte growth factor (HGF), also known as scatter factor. Aberrant activation via overexpression or mutation leads to increased tumor cell proliferation, survival, invasion/metastasis (especially through epithelial-mesenchymal transition [EMT]), angiogenesis. Therapeutic strategies target this axis with small molecule inhibitors, monoclonal antibodies, and antagonists to suppress tumor progression.
- Other names
- c-MetHepatocyte Growth Factor Receptor (HGFR)MNNG HOS transforming gene
02
Mechanism of action
Kinase inhibition; ligand-receptor blocking; dimerization prevention
03
Biological functions
Cell proliferationCell survivalCell motilityMorphogenesisAngiogenesisTissue regenerationWound healingEpithelial-mesenchymal transition (EMT)
04
Disease associations
CancerTumor growthTumor invasionMetastasis
05
Safety considerations
On-target toxicitiesOff-target toxicitiesResistance developmentCompensatory pathway activation
06
Interacting drugs
Small molecule MET kinase inhibitors
3 more in the full profile.
07
Biomarkers
MET expression levelMET gene mutationsHGF expression level
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