Mesenchymal Stem Cell-Derived Extracellular Vesicles (MSC-EVs)

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are nano- to micro-sized, lipid bilayer-enclosed particles secreted by mesenchymal stem cells (MSCs). These vesicles serve as mediators of intercellular communication and play a significant role in tissue regeneration, immunomodulation, and the delivery of bioactive molecules. They include exosomes, microvesicles, and apoptotic bodies, and carry proteins, lipids, mRNAs, miRNAs, and other non-coding RNAs. They interact with target cells through ligand-receptor interactions and internalization, modulating gene expression and cellular behavior. While showing promise in preclinical studies for various indications, clinical translation faces challenges in standardization, manufacturing, safety, and targeting.

Other names

Mesenchymal stromal cell-derived extracellular vesiclesMSC-derived EVsMSC extracellular vesiclesMesenchymal stem cell EVs

Ligand-receptor interactions trigger downstream signaling; Internalization via receptor-mediated endocytosis or membrane fusion allows direct delivery of EV cargo into the cytoplasm, enabling functional transfer of mRNA/miRNA for protein synthesis or gene regulation within recipient cells.