Mesenchymal Stem Cell-Mediated Delivery (MSC-Mediated Delivery)

Mesenchymal stem cell (MSC)-mediated delivery is a therapeutic approach that utilizes MSCs as vehicles for transporting therapeutic agents to specific target tissues or disease sites. MSCs possess inherent homing ability to sites of injury, inflammation, or tumors. They can deliver drugs, nanoparticles, genes, or proteins through various mechanisms, including paracrine secretion, direct transfer, and controlled drug release. This approach offers advantages such as biocompatibility, targeted delivery, and reduced off-target effects. Ongoing research focuses on improving homing efficiency, cargo loading techniques, and overall therapeutic efficacy.

Other names

MSC DeliveryMesenchymal Stem Cell TherapyMSC-based Drug Delivery

MSCs act as carriers to deliver therapeutic agents to target tissues through homing, paracrine secretion (e.g., EVs, cytokines), direct transfer via gap junctions/tunneling nanotubes, or controlled drug release.