Mesenchymal stem cell recruitment

Mesenchymal stem cell recruitment refers to the multi-step process by which MSCs are attracted to, migrate toward, and engraft within sites of tissue injury or inflammation. This process is governed by a complex interplay of chemokines (such as CXCL12/SDF-1), growth factors (like TGFβ1), and adhesion molecules (including selectins, integrins, and CD44), as well as matrix metalloproteinases that facilitate transmigration. MSC recruitment is essential for the therapeutic effects of stem cell-based tissue regeneration and repair, but is not itself a molecular drug target—rather, it is an outcome modulated by manipulating the signaling environment and receptor expression profiles of MSCs in vivo and in vitro. While no drugs specifically "interact" with this process as a single target, it can be modulated by compounds and growth factors such as TGFβ1, CXCL12, and TNFα. Assessment of recruitment may include evaluating cell surface markers like CXCR4, CD44, and integrins.

Other names

MSC homingMSC migrationMSC recruitment