Mesenchymal stromal cell from adipose tissue (MSC (adipose tissue); AT-MSC)

Mesenchymal stromal/stem cells derived from adipose tissue are multipotent adult stem cells characterized by their ability to differentiate in vitro and in vivo into multiple lineages, including osteogenic (bone), chondrogenic (cartilage), adipogenic (fat), myogenic (muscle), neurogenic (neuronal), and endothelial (vascular) cells[1][2][3][5][6][7]. They are abundant, accessible, and can be isolated from human adipose tissue, such as through liposuction procedures[5][6]. These cells express a characteristic set of surface markers (e.g., CD73, CD90, CD105) and lack hematopoietic markers[5]. Their differentiation is governed by signaling pathways (e.g., TGF-β/BMP, Wnt, Notch, Hedgehog)[2]. Adipose tissue MSCs are widely used in regenerative medicine and studied for their tissue repair, immunomodulatory, and paracrine effects[5]. However, the process of differentiation and their therapeutic efficacy can be negatively affected by disease states such as obesity, which induces cellular senescence and loss of stemness properties[4]. The supplied "target" string is not a canonical molecular entity but describes the functional capabilities of a cell population. Key clarification: The input is not a molecular target suitable for drug interaction nor a specific protein/gene; it refers to a cellular process or cell type function. For therapeutic targeting or structured database entries, this is incorrect as a target, and should be revised or narrowed to specify an actual molecule (e.g., a receptor, enzyme, or regulatory gene) involved in these lineage differentiation processes.

Other names

Adipose-derived mesenchymal stem cellAdipose tissue-derived mesenchymal stem/stromal cellAT-MSCASC (Adipose-derived stromal cell)