Mesenchymal Stromal Cells (MSCs)

Mesenchymal stromal cells (MSCs) are multipotent adult stem cells found in various tissues. They play a central role in tissue repair and regeneration through paracrine signaling, immunomodulation, limited direct differentiation, cellular interactions, and matrix remodeling. MSCs secrete bioactive molecules that promote cell survival, proliferation, and migration; enhance angiogenesis; regulate inflammation; and remodel the ECM. They have therapeutic applications in wound healing, chronic ulcer treatment, fibrosis reduction, and modulation of immune-mediated diseases.

Other names

Mesenchymal Stem CellsMSCs

MSCs exert therapeutic effects through paracrine signaling (secretion of growth factors, cytokines, chemokines, and extracellular vesicles), immunomodulation (suppression of inflammation and promotion of pro-reparative macrophage polarization), limited direct differentiation, cellular interactions/niche support, and matrix remodeling.