Target intelligence / Profile preview

Mesothelin (MSLN)

Target: MSLN
Molecular classification: Glycoprotein, Cell surface protein

Overview

Mesothelin is a cell surface glycoprotein overexpressed in several aggressive human cancers, including mesothelioma, pancreatic, ovarian, and lung adenocarcinoma. It is involved in cell adhesion, potentially through interaction with MUC16/CA125, and is a target for cancer diagnostics and therapeutics due to its restricted expression in normal tissues and high prevalence in tumors.

Other names: MPFMegakaryocyte Potentiating FactorSMRPSoluble Mesothelin-Related Peptide

Mechanism of action

Recombinant immunotoxins and monoclonal antibodies targeting mesothelin induce tumor cell death through various mechanisms, including antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), and/or deliver cytotoxic payloads directly to tumor cells.

Biological functions

Cell adhesionTumor implantationPeritoneal metastasis

Disease associations

CancerMalignant mesotheliomaPancreatic adenocarcinomaOvarian cancerLung adenocarcinomaCholangiocarcinomaTriple-negative breast cancer

Safety considerations

On-target, off-tumor toxicity due to limited mesothelin expression in normal tissuesImmunogenicity of therapeutic antibodies and immunotoxins

Interacting drugs

SS1P/CAT‐5001 (recombinant immunotoxin)

1 more in the full profile.

Biomarkers

Serum mesothelin levels (for mesothelioma)Mesothelin expression in tumor tissue

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