Messenger RNAs bearing miR-148a-5p seed-complementary sites (miR-148a-5p targets)

Messenger RNAs (mRNAs) bearing miR-148a-5p seed-complementary sites represent the collective group of transcripts post-transcriptionally regulated by the microRNA miR-148a-5p. These mRNAs contain specific sequences, typically in their 3' untranslated regions (UTRs), that pair with the 5' 'seed' region of the miRNA, facilitating binding by the RNA-induced silencing complex (RISC) (PMID: 21454424). This interaction leads to gene silencing through either mRNA degradation or the inhibition of protein translation. miR-148a-5p is a critical regulator of diverse biological processes, including DNA methylation via its targeting of DNMT1 and apoptosis via BCL2 (PMID: 24607418). In various malignancies, such as hepatocellular and gastric carcinomas, miR-148a-5p often acts as a tumor suppressor; its downregulation leads to the pathological overexpression of these target mRNAs, promoting cell proliferation and metastasis (PMID: 24333734). Therapeutic intervention typically involves the use of miRNA mimics to restore the silencing of these mRNAs or antagomirs to inhibit miRNA activity in specific disease contexts. However, because a single miRNA can regulate hundreds of different mRNAs simultaneously, achieving high therapeutic specificity without off-target effects remains a significant challenge in drug development (PMID: 23873015).

Other names

miR-148a-5p target transcriptsmiR-148a-5p regulated mRNAsMicroRNA-148a-5p target geneshsa-miR-148a-5p targets

miRNA mimics bind to these mRNA sites to induce translational repression or mRNA cleavage via the RISC complex, while antagomirs prevent endogenous miRNA binding to de-repress the target mRNAs.