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Target intelligence / Profile preview
MET Proto-Oncogene Receptor Tyrosine Kinase (MET)
- Target
- MET
- Molecular classification
- Receptor Tyrosine Kinase, Enzyme, Receptor
01
Overview
MET is a receptor tyrosine kinase activated by Hepatocyte Growth Factor (HGF). It plays a crucial role in embryonic development, tissue regeneration, and wound healing. Aberrant activation of MET in cancer cells promotes tumor growth, survival, motility, invasion, and metastasis, making it a significant therapeutic target.
- Other names
- c-MetHepatocyte Growth Factor ReceptorHGFR
02
Mechanism of action
Small molecule inhibitors targeting the kinase activity; Monoclonal antibodies against MET or HGF; Engineered antagonists interfering with ligand-receptor interaction or downstream signaling components
03
Biological functions
Signal transductionCell proliferationCell survivalCell motilityCell migrationInvasionMetastasisAngiogenesisEmbryonic developmentOrganogenesisWound healingTissue regenerationNormal tissue repair
04
Disease associations
CancerPapillary renal carcinomaHereditary papillary renal cell carcinoma
05
Safety considerations
Resistance mechanismsOff-target effects of kinase inhibitorsAcquired resistance to targeted therapies
06
Interacting drugs
XL184/cabozantinib
2 more in the full profile.
07
Biomarkers
MET overexpressionMET amplificationMET mutationHGF expression
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