Metabolic activity during hypothermic storage

Metabolic activity during hypothermic storage refers to the collective changes in cellular metabolic processes when tissues, organs, or cells are stored at temperatures below physiological norm[1][5][6][7]. Hypothermia slows down biochemical reactions, reduces ATP consumption, alters glucose, glutamine, and lactate metabolism, and shifts metabolism from aerobic to anaerobic depending on oxygen availability[2][4]. The aim during hypothermic storage is to preserve cell viability and metabolic reserves for transplantation, research, or therapeutic applications[1][5]. Special preservation solutions (e.g., HypoThermosol-FRS, University of Wisconsin solution) are used to mitigate cold-induced cell injury, control oxidative stress, and prevent cell death by protecting mitochondrial function and metabolic substrates[1][2][4][5]. Hypothermic storage is not itself a molecular entity or direct drug target, but the modulation of metabolism under these conditions can influence cell fate, viability, and function during organ or cell transplantation. Thus, this query does not point to a singular molecule or receptor but to a broad physiological phenomenon.