Metabolic pathway in hepatocyte

"Metabolic pathways in hepatocytes" refers to the complex and highly regulated network of biochemical reactions that occur within liver cells. These pathways include gluconeogenesis, β‐oxidation of fatty acids, lipid metabolism, cholesterol synthesis, the pentose phosphate pathway, and the ornithine cycle for ammonia detoxification[2][1]. The integration and regulation of these processes are essential for maintaining systemic energy homeostasis and responding to changes in nutrient availability or physiological stress[2]. Dysregulation of these pathways is implicated in a range of diseases including non-alcoholic fatty liver disease (NAFLD), metabolic associated fatty liver disease (MAFLD), steatosis, fibrosis, and hepatocellular carcinoma[3][1]. Note on correctness: "Metabolic pathways in hepatocytes" is not a single molecular target but rather describes a collection of interconnected biochemical processes. It does not correspond to an individual protein or receptor that can be directly targeted by drugs; therefore it is not considered a therapeutic target per se. For structured data extraction or drug discovery purposes, more specific targets within these pathways—such as enzymes like microsomal triglyceride transfer protein (MTTP) or apolipoprotein B100—should be identified instead[3].

Other names

Hepatocyte metabolismLiver metabolic pathwaysHepatic metabolic network